Aubrey De Grey, in California. He imagines humen could live to 5,000, and misses Calment’s DNA tested. Photograph: Carlos Chavarria/ Redux/ eyevine
Novoselov wrote to Young at Guinness World Records about Calment in October 2018,” asking him to look attentively at the issues we elevated “. His response, says Novoselov, was ” a expose of invasion by Europe against everything civilised “; Young, he says, characterised his duty as a plot targeted from on high by” person important “. But its not surprising that Novoselov’s abrasive tactics have raised eyebrows; he has threatened Young, as well as Calment’s validators, with investigation by Sledkom, the Russian FBI.
The evidence for a Russian disinformation campaign is thin, but Zak’s article did have a second sponsor. The peer-reviewed version issued in Rejuvenation Research, the magazine devoted to life-extension research edited by Aubrey de Grey, the contentious gerontologist and life-extension advocate who has claimed that, by 2100, the human lifespan could reach 5,000 years. Even if Zak doesn’t believe it, the possibility that Calment did reach 122 is tantalising for De Grey.” Anyone who is the world record holder of longevity are of concern to those of us studying the biology of ageing ,” he tells me.
Speaking on the phone from London, where he is on a stopover between Berlin and his home in California, De Grey is evasive about whether his strategy is to force the exhaust of Calment’s blood test. But he does think it should be made available for science:” In the interests of saving lives, finding out more about ageing to eventually shelve ageing- then that’s actually quite important .” Would he miss his own study organization, Sens, to do the DNA testing? Not necessarily, he says,” but I will definitely are aware of the right kind of researchers to recommend “.
That analysis seems unlikely to happen any time soon. The Fondation Jean Dausset, a private genetic experiment centre in Paris, refuses even to confirm that it is keeping Jeanne Calment’s blood; just that it has a collection of biosamples it alone can use for research under anonymised situations. But Francois Schachter, the scientist who in the 1990 s founded its Chronos Project, the first genetic examination of centenarians in the nations of the world, has confirmed that her blood was taken and her DNA extracted.
Twenty years ago, the life-extension field promoted by dissenters like De Grey was outlaw discipline. Now, the landscape has changed: the technical means for ” hacking ” the human lifespan have come into being, and the sector is beginning to attract serious investment. In 2013, Google endowed $1.5 bn in an entire divide, Calico, devoted to” solving extinction “. PayPal co-founder Peter Thiel has given millions of dollars to Sens.
But Sens, according to its annual reports, has been running at heavy losses. De Grey says it has been investing the $13 m he put into the foundation in 2011 on research for anti-ageing therapies that will save” several million” lives. But it must start to pay its way; wouldn’t securing the DNA of the oldest girl in the world be a great publicity coup, as death-dodging tech billionaires pile into the sector? De Grey at-bats off this idea.” I get enough media attention as it is .”
If he could study Calment’s DNA, what might he expect to learn? De Grey specifically provides that supercentenarians’ genetic textile contains a high ratio of useful information,” because they have to get more things right in order to get to the age they do “. One obvious province of interest is how Calment bypassed cancer, coronary thrombosis, diabetes and other late-life killers.
Several scientists I spoke to believe that Calment’s genome should be made available for study; but they don’t are supportive of the space Zak and De Grey have seemingly attempted to force the foundation’s side. One upshot of promoting the switch theory, they point out, is that they have alienated family members whose own DNA might be crucial for a clearer understanding of Calment’s.
Earlier this month, a Russian news agency has declared that a woman who was purportedly 123 had died in the Astrakhan region of southern Russia. This is almost certainly impossible- even Novoselov thinks so; given her children’s ages, she would have given birth three times in her 50 s. But the narration underlines the need for gerontology to keep its house in order.
At the time of going to press, scientists from around the world were due to discuss the impact of the Calment affair on gerontology at a special meeting in Paris. As for her mortal remains, some fantasize the Fondation Jean Dausset might be more open to collaboration as anti-ageing science evolves- but it is unlikely to be with De Grey. Despite telling me that Jeanne Calment does not anatomy high on his priorities, he plans to devote another matter of Rejuvenation Research to age validation and Calment next year.
In Arles, in spite of everything, the counter-investigation group are tickled by the idea that Jeanne Calment might have been a lord fraudster.” I would really like the permutation fib is correct, like in the romances I cherish reading ,” says Cecile Pellegrini.” I find that kind of thing super-exciting. If it’s actually true-life, she was really something !” But perhaps the doyenne has something else to school the would-be immortals of Silicon Valley: what extra hassle would 5,000 years of live bring, if we can’t get the record straight on a single everyday life-time?
* Additional reporting by Marc Bennetts
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